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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T77907 Tusamitamab ravtansine

HuMAb2-3-SPDB-DM4,SAR-408701

Tusamitamab ravtansine (SAR-408701) 是一款针对CEACAM5的人源化单克隆抗体与DM4细胞毒性药物经活性分子连接而成的抗体-药物偶联物(ADC),专门靶向CEACAM5表达的肿瘤细胞。

化合物

Tusamitamab ravtansine
Cat.No: T77907
Synonym: HuMAb2-3-SPDB-DM4,SAR-408701
Target:
Cat. No. Product Name Species Expression System
TMPY-05050 CEACAM5 Protein, Cynomolgus, Recombinant (His)

carcinoembryonic antigen-related ...

Cynomolgus HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.5 kDa and the accession number is XP_005589491.1.
TMPY-01647 CEACAM5 Protein, Human, Recombinant (His)

CD66e,CEA,carcinoembryonic antigen-rel...

Human HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A0A024R0K5.
TMPY-06535 CEACAM5 Protein, Cynomolgus, Recombinant (hFc)

carcinoembryonic antigen-related ...

Cynomolgus HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.76 kDa and the accession number is XP_005589491.1.
TMPY-06860 CEACAM5 Protein, Cynomolgus, Recombinant (His & Avi)

carcinoembryonic antigen-related ...

Cynomolgus HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 75.29 kDa and the accession number is XP_005589491.1.
TMPY-06882 CEACAM5 Protein, Human, Recombinant (hFc & Avi), Biotinylated

CD66e,CEA,carcinoembryonic antigen-rel...

Human HEK293 Cells
CEACAM5 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 99.87 kDa and the accession number is NP_004354.2.
TMPY-06636 CEACAM5 Protein, Mouse, Recombinant (hFc)

carcinoembryonic antigen-related ...

Mouse HEK293 Cells
CEACAM5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 129.35 kDa and the accession number is Q3UKK2-1.
TMPY-05285 CEACAM5 Protein, Human, Recombinant (His), Biotinylated

carcinoembryonic antigen-related ...

Human HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A0A024R0K5.
TMPY-06534 CEACAM5 Protein, Mouse, Recombinant (His)

1600029H12Rik,Psg30,carcinoembryonic antigen

Mouse HEK293 Cells
CEACAM5 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.07 kDa and the accession number is Q3UKK2-1.
TMPY-05320 CEACAM5 Protein, Human, Recombinant (hFc)

CD66e,CEA,carcinoembryonic antigen-rel...

Human HEK293 Cells
CEACAM5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.1 kDa and the accession number is P06731.3.
TMPY-06356 CEACAM5 Protein, Human, Recombinant (His & Avi), Biotinylated

CD66e,CEA,carcinoembryonic antigen-rel...

Human HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.59 kDa and the accession number is NP_004354.2.
TMPH-01048 CEACAM5 Protein, Human, Recombinant (E398K, His)

Carcinoembryonic antigen-related ...

Human HEK293 Cells
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5...
TMPK-01299 CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)

Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-...

Cynomolgus HEK293 Cells
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His)

GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPY-05387 SLAMF7 Protein, Human, Recombinant (hFc)

SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-04318 GRIK2 Protein, Human, Recombinant (hFc)

GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...

Human HEK293 Cells
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-05547 SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPJ-00854 ETS1 Protein, Human, Recombinant (His)

V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...

Human E. coli
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05498 SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...

Human HEK293 Cells
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363 SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

CEACAM5 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05050
Species: Cynomolgus
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His)
Cat.No: TMPY-01647
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (hFc)
Cat.No: TMPY-06535
Species: Cynomolgus
Expression System: HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (His & Avi)
Cat.No: TMPY-06860
Species: Cynomolgus
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06882
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-06636
Species: Mouse
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05285
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06534
Species: Mouse
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05320
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06356
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Human, Recombinant (E398K, His)
Cat.No: TMPH-01048
Species: Human
Expression System: HEK293 Cells
CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)
Cat.No: TMPK-01299
Species: Cynomolgus
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (aa 1-529, His)
Cat.No: TMPY-05308
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05387
Species: Human
Expression System: HEK293 Cells
GRIK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04318
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05547
Species: Human
Expression System: HEK293 Cells
ETS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00854
Species: Human
Expression System: E. coli
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05498
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01357
Species: Human
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01363
Species: Human
Expression System: HEK293 Cells
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